Barriers to Oral Drug Delivery
Emisphere's Eligen® Technology overcomes major obstacles to effective oral delivery including:
The high acid content and enzymes of the digestive tract can degrade some drugs, particularly protein and peptide drugs, before they are absorbed into the bloodstream. The Eligen® Technology can inhibit acid and peptidase mediated degradation allowing sufficient time for the drug to be absorbed via the GI epithelium.
Many macromolecules and charged compounds are poorly absorbed through biological membranes due to poor partitioning properties. Emisphere’s delivery agents interact with the drug molecule to transiently alter these properties and facilitate absorption.